Biotech Corner: Monoclonal Antibody Companies (Part 1)

Biotech Corner: Monoclonal Antibody Companies (Part 1)

From The latest Market Shadows newsletter: A Failure to Communicate: Numbers, Rates & Lies

By Pharmboy of Market Shadows

Biotech stocks are my passion. My alter-ego is a scientist, working in the field of biotech, and I love it.

The days of becoming the next Genentech or Amgen are over. Big Pharma will become the juggernauts that will sell and market the drugs, while smaller companies will fill the pipelines and keep the juggernauts running.  Premiums being paid to buy phase 1 compounds are increasing. Phase 1 includes all preclinical testing. The larger companies are paying 100M for phase 1 compounds, whereas it only takes about 25M to get to phase 1. (Phase 1 compounds are those that have completed very early trials, but for which there is no efficacy data yet.)

Typically, biotechs are more efficient than Big Pharma companies. The return on investments for biotech companies, if they are efficient and successful, is north of 300%. That is not a bad return….but biotechs are high risk and often have many failures that eat into those potential gains.

I am going to focus on a few companies that have a communal relationship to a technology – the monoclonal antibody (mAb) technology. Monoclonal antibody technology had its first success in 1986, when muromonab was approved for transplant rejection. mAb’s are specific to a particular target.  When a mAb binds to its target, it stimulates an immune response. The immune system then attacks and ‘kills’ the target.

Monoclonal Ab technology has exploded, with ‘tags’ now being attached to the mAb. Those tags can be radionucleotides, anti-neoplastic agents, other antibody-drug conjugates (ADC), and other proteins.  All of these tags are released when the mAb binds to its target, the conjugates then perform their actions. There is a very good review here.

 

 

There are several companies that have employed the technology of attaching a drug (ADC) to their specific mAb. One company that has both in-house and licensed-out technology is Seattle Genetics (SGEN, $25.31). SGEN is poised for growth – IF a few of its mAb’s prove to be effective in treading various blood cancers. The company licenses out its technology to Roche (Genentech), Celldex (CDLX), Progenics (PGNX), Abbott (ABT), Astellas and many other companies for various types of cancer. In-house, its pipeline is heavily invested in Brentuximab Vedotin (Adcetris), but there are other drugs in SGEN’s pipeline.

Brentuximab Vedotin (Adcetris) is a monoclonal antibody that targets the protein CD30, which is expressed on immune cells and in several different cancer types, including on classical Hodgkin Lymphoma cells.  CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. The CD30 receptor is expressed by activated, but not resting, T and B cells. (T and B cells are different kinds of lymphocytes,* which are a type of white blood cell.) Activating CD30 leads to apoptosis – cell death. (Wikipedia).

Adcetris is approved in a small market for treating anaplastic large cell lymphoma (ALCL) as well as relapsed Hodgkin lymphoma. SGEN has 10 additional clinical trials ongoing for Adcetris.  Should the ADC work in one or several different cancer indications, revenues will roll in and SGEN might become a takeout target for Roche or another Big Pharma player. (For more on SGEN, visit the Hammer Stock Blog.)

 

Adding to my long stock positions

I am going to initiate several long positions in my Virtual Stock Portfolio at Market Shadows:

SGEN ($25.31) – buying 100 shares.

CLDX ($6.03) – buying 100 shares (there was a typo in the ticker symbol)

PGNX ($2.36) – buying 500 shares.

 

Pharmboy’s Virtual Stock and Options Portfolio:

In the Virtual Stock and Options Portfolio, I am going to buy one March $25/30 bull call spread for $1.70, and sell one March 2013 $25 put for $2.55 for a net $0.85 credit, on Monday Dec. 3, 12.

Alternatively, for a buy-write position, I like buying 100 shares of stock and selling one March 2013 $25 call and put for $5.35 combined.

 

*A lymphocyte is a type of white blood cell in the vertebrate immune system. Under the microscope, lymphocytes can be divided into large lymphocytes and small lymphocytes. Large granular lymphocytes include natural killer cells (NK cells). Small lymphocytes consist of T cells and B cells. (Wikipedia)

 

Read Monoclonal Antibodies Part 2 here > 

From The latest Market Shadows newsletter: A Failure to Communicate: Numbers, Rates & Lies

Individual articles featured in the Market Shadows newsletter become available over the weekend, here on the website.
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  1. [...] Sector Exploration: Biotech Corner – Monoclonal Antibodies & Companies Involved in the Technology (Part 1) [...]

  2. [...] Sector Exploration: Biotech Corner – Monoclonal Antibodies & Companies Involved in the Technology (Part 1) [...]

  3. [...] Sector Exploration: Biotech Corner – Monoclonal Antibodies & Companies Involved in the Technology (Part 1) [...]

  4. [...] Sector Exploration: Biotech Corner – Monoclonal Antibodies & Companies Involved in the Technology (Part 1) [...]

  5. [...] In Part 1 of Monoclonal Antibody Companies, I highlighted a leader in the field, Seattle Genetics (SGEN). It’s technology incorporates monoclonal antibodies (mAb), and also allows for having a drug ‘tagged’ on the mAb, so that when the mAb attaches to a cell, it is ‘ingested’ into the cell, and the drug is released. The antibody-drug combination is called an antibody-drug conjugate (ADCs). ADCs are “empowered” antibodies. They are designed to use the targeting ability of the antibody to precisely deliver the toxic drug where it’s needed, increasing its effectiveness and decreasing side effects. [...]

  6. [...] Sector Exploration: Biotech Corner – Monoclonal Antibodies & Companies Involved in the Technology (Part 1) [...]

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